ACR Criteria for diagnosis of Wegener’s Granulomatosis

In  1990 American College of Rheumatology  devised a Criteria for diagnosis of Wegener’s Granulomatosis (WG), now known as Granulomatosis with Polyangitis (GPA)

Picture shows clinical features-

Criteria Included

1. Nasal or oral inflammation: painless or painful oral ulcers or purulent or bloody nasal discharge

2.Abnormal chest radiograph: presence of nodules, fixed infiltrates or cavities

3.Urinary sediment: microhematuria (>  5 red blood cells per high power field) or red cell casts in urine sediment.

4.Granulmatous inflammation on biopsy: granulomatous inflammation within the wall of an artery or in the perivascular or extravascular area (artery or arteriole)

Requirements: ≥ 2 of the above 4 criteria are required for classification as GPA.  Sensitivity 88.2%, specificity 92.0%.

The American College of Rheumatology 1990 criteria for the classification of Wegener’s Granulomatosis.  

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